Yes, it is. For solutions such as Google MultiDex, the latest patch tool integrates multiple DEX files into a single, complete DEX file. The tool then analyzes the differences between the old and new DEX files to create a patch package. This process ensures that a patch package is created correctly, regardless of the number of DEX files that the APK contains.
Note: Patch packages can be created only for APKs that are not hardened. Hardening changes the DEX structure of an APK, causing patch generation to fail.
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